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一、【研究领域】
1、神经退行性和代谢性疾病药物靶点的确定及药效学评价
2.民族药物网络药理学机制研究
二、【主持的主要科研项目】
1.国家自然科学基金地区基金项目.NO. 81260489.内质网应激PERK信号通路
与阿尔茨海默病的关系及大蒜素的保护作用研究.2012-2014
2.国家自然科学基金地区基金项目.NO. 81460547.Cdk5介导的AM**α2蛋白磷
酸化在糖尿病脑病中的作用机制研究.2014-2018
3.国家自然科学基金地区基金项目.NO. 81660598.海马Fndc5基因启动子区组蛋
白甲基化修饰在糖尿病脑损伤中的作用.2016-2020
4.国家自然科学基金地区基金项目.NO. 81860636LncRNA NONRATG022419调控
PRG-1的表达在糖尿病脑损伤中的作用及机制研究.2018-2022
5.湖南省教育厅重点项目.NO.14A117主持Cdk5介导的AM**蛋白磷酸化在糖尿
病脑损伤中的作用机制研究.2014-2018
【主要学术论文】
1.Yan Li,Qiong Xiang,Yu-Han Yao,Jing-Jing Li,Yan Wang,Xian-Hui Li（通讯）.Inactivated AM**-α2 promotes the progression of diabetic brain damage by Cdk5 phosphorylation at Thr485 site.Biochimie. 2020 Jan;168:277-284
2.Qiong Xiang , Jing-Jing Li , Chun-Yan Li , Rong-Bo Tian ,Xian-Hui Li（通讯）Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression.CNS Neurol Disord Drug Targets. 2019;18(10):791-797.
3.Xiang Q,Xian-Hui Li（通讯）, Fang XX, Jia J, Ren J, Dong YC, Ou-Yang C.Alterations of synaptic plasticity in aged rats: Evidence of functional and morphological studies.Technol Health Care. 2018;26(2):271-278.
4.Xiang Q,Xian-Hui Li（通讯）, Yang B, Fang XX, Jia J, Ren J, Dong YC, Ou-Yang C, Wang GC.Allicinattenuates tunicamycin-induced cognitive deficits in rats via its synaptic plasticity regulatory activity.Iran J Basic Med Sci. 2017 Jun;20(6):676-682.
5.Zhu YF,Xian-Hui Li（通讯）, Yuan ZP, Li CY, Tian RB, Jia W, Xiao ZP.Allicin improves endoplasmic reticulum stress-related cognitive deficits via PERK/Nrf2 antioxidative signaling pathway.Eur J Pharmacol. 2015 Sep 5;762:239-46.
6.Xiang Q, Yu C, Zhu YF, Li CY, Tian RB,Xian-Hui Li（通讯）.Nuclear factor erythroid 2-related factor 2 antibody attenuates thermal hyperalgesia in the dorsal root ganglion: Neurochemical changes and behavioral studies after sciatic nerve-pinch injury.Injury. 2016 Aug;47(8):1647-54.
7.Xiang Q, Zhang J, Li CY, Wang Y, Zeng MJ, Cai ZX, Tian RB, Jia W,Xian-Hui Li（通讯）Insulin resistance-induced hyperglycemia decreased the activation of Akt/CREB in hippocampus neurons: Molecular evidence for mechanism of diabetes-induced cognitive dysfunction.Neuropeptides. 2015 Dec;54:9-15.
8.Xian-Hui Li, Xin X, Wang Y, Wu JZ, Jin ZD, Ma LN, Nie CJ, Xiao X, Hu Y, Jin MW. Pentamethylquercetin protects against diabetes-related cognitive deficits in diabetic Goto-Kakizakirats.JAlzheimers Dis. 2013;34(3):755-67.
9.Xian-Hui Li, Li CY, Lu JM, Tian RB, Wei J.Allicin ameliorates cognitive deficits ageing-induced learning and memory deficits through enhancing of Nrf2 antioxidant signaling pathways.Neurosci Lett. 2012 Apr 11;514(1):46-50.
10.Xian-Hui Li, Li CY, Xiang ZG, Hu JJ, Lu JM, Tian RB, Jia W.Allicin ameliorates cardiac hypertrophy and fibrosis through enhancing of Nrf2 antioxidant signaling pathways.Cardiovasc Drugs Ther. 2012 Dec;26(6):457-65.
